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Despite the well-tolerated nature of GHRP treatment, chronic administration may lead to desensitization of the GH response and other collateral effects, necessitating further understanding before replacing conventional GH treatment

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A 2008 study in The FASEB Journal (Atamna et al.) found that low doses (0.54 mg/kg) in animals and humans stimulated mitochondrial function for enhanced cellular energy was well-tolerated

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