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CJC-1295 (No DAC) Mechanism of Action In preclinical studies, CJC-1295 (no DAC) acts as a selective GHRH receptor agonist

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JARDIANCE was evaluated in 7,020 adult patients with type 2 diabetes and established cardiovascular disease (eGFR greater than or equal to 30 mL/min/1.73 m2) in the EMPA-REG OUTCOME trial, in a total of 9,718 patients with heart failure (eGFR greater than or equal to 20 mL/min/1.73 m2) in the EMPEROR-Reduced and EMPEROR-Preserved trials, and in 6,609 adult patients with chronic kidney disease (eGFR 20 to 90 mL/min/1.73 m2) in the EMPA-KIDNEY study

Orforglipron Name: Orforglipron Manufacturer: Eli Lilly Current stage: Expected to submit for regulatory approval by the end of 2025 Takeaway: Less effective than injectables for mean weight loss, but a daily pill could suit some patients better