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French noted

The result could further be an indication of a substantial and rising off-label prescribing of GLP-1 RAs, something which aligns with previous indications of an increasing off-label prescribing and misuse of GLP-1 RAs [28,29,30,31, 60], together with a media picture of substantial misuse which has been reported in recent years [23, 26, 27, 34, 36, 68]

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Dose adjustments are made proactively to manage side effects while maintaining therapeutic efficacy