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Abbreviations AADs: Anti-arrhythmic drugs cgr: Cardiac glycoside reductase CKD: Chronic kidney disease CRP: C-reactive protein CYP: Cytochrome ERP: Effective refractory period ESRD: End-stage renal disease GM: Gut microbiota GPCR: G-protein coupled receptor DC: Dendritic cells IL: Interleukin LPS: Lipopolysaccharide MATE: Multi-drug and toxin extrusion protein NF- k B: Nuclear factor- kappa ligand B NOS: Nitric oxide synthase OATP: Organic anion transporter polypeptide P-gp: P-glycoprotein PK: Pharmacokinetic SCFA: Short-chain fatty acid Sult: Sulfotransferase TLRs: Toll-like receptors TMA: Trimethylamine TMAO: Trimethylamine oxidation metabolite TNF: Tumor necrosis factor-alpha References De la Fuente M (2021) The role of the microbiota-gut-brain axis in the health and illness condition: a focus on Alzheimers disease

Rat studies with induced arthritis show reduced cartilage degradation and improved limb mobility scores following BPC-157 administration

Kansas ranked 15th nationally for obesity, and Wichita's own numbers reflect the state trend, with roughly one in three adults qualifying as obese

The next decade may redefine obesity and metabolic disease management more dramatically than any era since the discovery of insulin.

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