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If you are on oral birth control, weight loss medication can decrease the effectiveness

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Biomarker Context and Dosing Response Variability Dosing efficacy varies significantly across individuals due to differences in metabolic rate, insulin sensitivity, glucagon-like peptide-1 receptor expression, and gastrointestinal motility

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This suggests that healthcare providers can use a dose-titration strategy to achieve the balance between weight-loss efficacy and tolerability for individual patients