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Some patients also report that the treatment helps to quiet food noise, or intrusive thoughts about food and eating, a struggle for many who have lived with overweight for a long time

3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993

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People who stop taking GLP-1s typically regain some of the weight they've lost and may lose some of the other benefits of the drugs, like the reduced risk of cardiovascular disease