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It is challenging to define cellular senescence in erythrocytes, since these cells are terminally differentiated and their aging is not accompanied by the senescence-associated secretory phenotype (SASP) like in the case of nucleated cells [495]

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People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use GLP-1 receptor agonists because of potential tumor risks observed in animal studies

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