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While 100 nM MitoQ only minimally increased DPI-induced cell death ( Figure 1C ), higher MitoQ concentrations significantly enhanced DPI-mediated cell toxicity as measured by an increased PI uptake after 24h, in a MYCN-dependent fashion ( Figure 1E )

It is also required for synthesis of nucleic acid, notably DNA, the metabolism of fatty acids and amino acids in the mitochondria, and in delivering SAMe, the universal methyl donor (16) (30)

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Compared with the results of prototype BPC157 in rats, the pharmacokinetic parameters of [ 3 H]BPC157 evaluated based on total radioactivity changed markedly, indicating the significant metabolism and decomposition process of BPC157 in vivo