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Clinical presentation can include melena or hematuria, mucosal bleeding, skin bruises, and osteopenia/osteoporosis

J Neurosci 29:222233 [DOI] [PMC free article] [PubMed] [Google Scholar] Yu YJ, Dhavan R, Chevalier MW, Yudowski GA, von Zastrow M

It is a critical cofactor for the synthesis of collagen, the primary structural protein in our skin, bones, and connective tissues

In addition, it reduces photo-damage and discoloration of the skin, improving its overall appearance

Therefore, the beneficial effects of ROS are achievable within physiological levels and deviation from redox window (as oxidative or reductive stresses) [29] will be associated with different pathologies including neurodegenerative diseases [30] diabetes [31] cardiovascular disease and atherosclerosis [32] rheumatoid arthritis [33] respiratory disease [34] carcinogenesis [35] ageing [36] female reproductive disease, pregnancy complications and recurrent pregnancy loss [37]