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Study findings highlight that these drugs predominantly encourage patients to reduce their fat and sweet food intake, reducing total caloric intake by 16-39%

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(2) enhanced aromatase activity in adipose tissue, leading to increased local and systemic estrogen levels, thereby stimulating pituitary prolactinocytes to synthesize and secrete prolactin

While not statistically significant due to wide confidence intervals, the trend actually favored tirzepatide

Tohoku J Exp Med 206:131139 Chiou H-YC, Lin M-W, Hsiao P-J, Chen C-L, Chiao S, Lin T-Y, Chen Y-C, Wu D-C, Lin M-H (2019) Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the central nervous system