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If the DMF content compared to diethyl PMEA is greater than 12%, the mixture at no more than 80 is concentrated in vacuo , the contents are cooled to below 40, dichloromethane (7.0 kg) is added and the contents at about 25 (20-40) are agitated to dissolve the solids

Regarding pharmacotherapy, Dutch standards recommend a stepwise introduction of treatments based on glycated haemoglobin (HbA1c), starting with metformin then sequentially adding sulphonylureas, followed by the addition of insulin or glucagon-like peptide-1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP-4) inhibitors as required to achieve and maintain glycaemic targets [9]

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