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The natural form of folate, 5-methylTHF (methylfolate), offers several advantages compared to folic acid: it does not mask B12 deficiency, it is already a biologically active form, it does not cause unmetabolized folic acid in blood, and it is absorbed and utilized at least as well as folic acid

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Nevertheless, intravenously administered Se at a high dose has demonstrated primary pro-oxidant activity, which may be helpful in the early stages of the disease [18]

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Kennedy Medical Center, Edison, New Jersey with non-lacunar ischemic infarcts