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METFORMIN Metformin is a biguanide agent used as a first-line treatment for T2DM because of its ability to reduce hepatic glucose production and increase peripheral tissue glucose uptake

The conversion of ribonucleotides to deoxyribonucleotides (through the action of ribonucleotide reductase) requires NADPH as the electron source, therefore, any rapidly proliferating cell needs large quantities of NADPH

Rather than lowering estrogen levels directly, it selectively prevents estrogen from exerting effects where it is most problematic, while allowing estrogen signaling elsewhere in the body

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