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Reporter response quantification Reporter response quantification was conducted similar as in Wink et al

M., Burr, M

Its deficiency can lead to scurvy due to impaired collagen formation affecting bones, blood vessels and skin

In consequence, lipid peroxidation products regulate multiple signaling cascades implicated in apoptosis and inflammation, such as the NF-B pathway, in which reactive aldehydes activate NF-B by promoting IB degradation and phosphorylation-mediated inactivation of anti-apoptotic Bcl-2, thereby enhancing pro-inflammatory signaling [45]

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