Only 1.56% of administered drug molecules can enter target cells if the efficiency of each step in the ADC mechanism is assumed to be 50% (biodistribution, binding to antigen, internalization, release of payload, intracellular stability of payload, and payload binding to target) (Teicher and Chari, 2011)
If youre experiencing nausea or diarrhea, increase your fluid intake accordingly to maintain proper fluid and electrolyte balance
Sinclair R, Tosti A, Schwartz JR, et al
have conducted in-depth studies on this target, continuously refining and developing several generations of compounds based on the structure of pan-JNK inhibitor 42 , which was identified through an in-house kinase-focused library screening
Figure S24