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Dosing Strategy: 1

Free Confidential Request a callback A weight-loss coordinator calls you within one business day

Receptor Selectivity and Off-Target Considerations Orforglipron's selectivity for the GLP-1 receptor over related class B GPCRs has been characterized through extensive in vitro profiling

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In STEP 1 the middle of the group lost close to 15% of their starting weight over 68 weeks, but individual results ranged from substantial loss to almost none, and everyone in the trial was also following a reduced-calorie diet and increased physical activity