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A 5% dosing error from syringe measurement imprecision is functionally insignificant in long-term studies where inter-subject variability exceeds 1520%

These data show that clientizing mutations outside the dibasic motif enhance coatomer binding affinity compared to the endogenous canonical Lys -x- Lys -x-x CT motif, suggesting that the S x CT residue has a key modulatory function in coatomer interactions

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