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In conclusion, it seems that GLP-1/exendin-4 acts in the VMH and LH, modulating the activation status of AMPK and S6K1 in response to glucose fluctuations, helping to improve pathophysiological states such as obesity and insulin resistance

These data suggest that in the absence of GSH synthesis, the liver accumulates GSH precursors and can re-route them into alternative metabolic pathways

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Magnetic resonance spectroscopy (MRS) allows biochemical concentrations of glutathione, glutamate, and other metabolites to be measured non-invasively in vivo

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