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Biochem Pharmacol 44, 165160

however, as the disease progresses these can often be seen with the naked eye, particularly when the iris is lightly pigmented and there is severe copper overload[13]

of salts

Clark et al ., [16] had provided pharmacokinetic safety validation, while Hagos et al ., [18] took these findings to mechanistic pathway modulation, making the two studies complementary and highly concordant in pharmacologic approach, although with variation in outcome measurement focus