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The combination of dasatinib and quercetin (DQ) has completed phase 1 clinical trials for Alzheimers disease, and navitoclax is currently in phase 3 clinical trials for myelofibrosis 29,30

"Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency"

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In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]