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Upon binding to the peripheral neuronal presynaptic membrane mediated by the heavy chain the toxin is internalized by receptor-mediated endocytosis

doi: 10.1016/j.nbd.2017.02.004 64 DesaiV.KalerS

Data were extracted as follows: (1) species, number exposed to drug of interest, number of controls, timing and duration of exposure, dose (drug/kg/time-interval and equivalents to maximum recommended human dosage or clinical dosage), fetal effects of maternal GLP-1 agonist or SGLT2 inhibitor exposure, (2) species, number exposed to drug of interest, number of controls, timing and duration of exposure, dose (drug/kg/time-interval and equivalents to maximum recommended human dosage or clinical dosage), the transfer of GLP-1 agonist or SGLT2 inhibitor in maternal milk and the effect of exposure during lactation on the neonate

The high practicality of the proposed HPLC method is further confirmed with CACI score of 82

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