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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

They discuss how modern sedentary lifestyles affect the body, the importance of thoracic spine mobility, and specific exercises designed to improve stability and flexibility

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The combination with helium-neon laser further enhanced these effects