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Interestingly, a phase 2 placebo-controlled preventive trial found that lovastatin may decrease the incidence of melanoma without reducing melanoma biomarkers [39]

Advances in molecular biology have further enhanced our understanding of G6PD deficiency, and now over 160 different gene mutations or mutation combinations have been identified

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Briefly, cells were lysed with NETN buffer (50 mM Tris, pH 8.0, 150 mM NaCl, 0.5% Nonidet P-40, 1 mM DTT) plus Xpert protease inhibitor cocktail solution (GeneDepot, Cat#P3100-001)

Spatial transcriptomics critically resolves the localization of this immune response, showing enrichment of immune cells, especially macrophages, in fibrotic areas (Figure 3)