these were bile acid metabolites such as cholate and chenodeoxycholate, lipid metabolites such as arachidonic acid, C16:0-LPC, C18:0-SM, docosapentaenoate, adrenic acid and stearoyl ethanolamide, metabolites involved in the metabolism of protein or amino acids, such as imidazole propionate, ADMA and creatine, and active metabolites or neurotransmitters such as the n-acetylputrescine, diacetylspermine, malonate
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These procedures are planned once in 15 to 20 days to give a significant improvement in 3 to 4 treatment sessions, though maintenance is required
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However, residual confounding is always a limitation to the observational design
