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doi: 10.1177/0961203309103152

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High levels of B12, or hypercobalaminemia, can be a sign of tissue breakdown, which releases B12 back into the bloodstream

Plasma concentrations decline significantly with age from ~200 ng/mL at age 20 to ~80 ng/mL by age 60 making it a compelling target for age-related tissue maintenance and periodontal health

Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death