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doi: 10.1155/2015/401630 247 KangMSJangHJKimJMJoHJParkKMChungYHet al

Indeed, other conditions that slow intracellular metabolism, such as inhibition of mTOR signaling or deprivation of certain amino acids, also appear to increase resistance to ferroptosis through GSH-conserving mechanisms that may be unrelated to nucleotide synthesis (Conlon et al, 2021)

This gap encourages further discussion and presents opportunities for the next stage in the development of antioxidant therapies

They compared how the drug is metabolized by the different strains and looked for variations in gene expression and changes in endogenous metabolites in response to acetaminophen administration

The precise mechanism(s) by which low GSH induces CYP2E1 and ALDH1A1 remain to be elucidated