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Somnolence was reported in 0.3% of patients treated with RYALTRIS and none of the patients who received placebo in 2-week studies in patients with seasonal allergic rhinitis [see Adverse Reactions (6.1)]
However, HE staining showed slight folding, shrinking and delamination of the basement membrane of seminiferous tubules in the rat testicular tissue, an increasing amount of sperm, insignificant damage to spermatogenesis, a lack of mature spermatogenic cells, a slightly disordered and sparse cell arrangement with 35 layers and visible cell polarity in groups C and D
Wakamatsu K, Nakao K, Tanaka H, Kitahori Y, Tanaka Y, Ojika M, Ito S (2019) The oxidative pathway to dopamine-protein conjugates and their pro-oxidant activities: implications for the neurodegeneration of Parkinsons disease