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These have demonstrated synergistic effects with photothermal and chemoradiation therapies in cervical models, significantly enhancing local cytotoxicity while maintaining tissue selectivity [211]

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling

The increase in sphingomyelins can interfere with signaling pathways, including phosphatidylinositol 3-kinase (PI3K)/AKT and MAPK, inhibiting cancer cell proliferation and growth (222)