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Optimized LC-MS/MS parameters for the analysis of eicosanoids are in accordance with previous research ( Inhibition of Cyclooxygenase 1 (COX-1) and Cyclooxygenase 2 (COX-2) in Cell-Free Assays Cyclooxygenase (COXs) can convert AA to PGG 2 , and further reduce PGG 2 to PGH 2

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Orange peel contains less of it than some other citruses (like bergamot or lime), but still, be careful with it especially if it is in a product for daytime use

It is thought to influence the sleep-wake cycle by affecting neurotransmitter activity, including that of gamma-aminobutyric acid (GABA) and serotonin