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This synergy occurs because the two pathways converge on the same somatotroph cells, and their combined start produces a multiplicative rather than merely additive effect

The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)

Role of nutritional supplements in selected dermatological disorders: a review