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As with any medication, adjusting to GLP-1 therapy can come with some side effects, particularly digestive issues like nausea, diarrhea, and constipation

Before considering the combination of phentermine and semaglutide, patients and providers should explore alternative evidence-based weight management strategies that may offer effective results with potentially lower risk profiles

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Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)