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From a mechanistic point of view, concerns about pancreatitis and hepatobiliary disease stem from the way incretin-based drugs alter digestion and bile flow

Nausea peaks 25 days after a dose-up

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Stacking them adds redundant signaling, raises side-effect risk, and is not a pattern used in clinical trials

82073429, 82273510, 82430101), Innovation Program of Shanghai Municipal Education Commission (No.2019-01-07-00-07-E00046), Clinical Research Plan of SHDC (No.2020CR1014B, 22022302, 2020CR6022), Shanghai Science and Technology Development Funds (24YF2738100)