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Start smaller than feels necessary

But for a patient whose histamine bucket is already overflowing, this exertional histamine release can be the tipping point that triggers a severe, multi-day systemic crash, characterized by debilitating fatigue, muscle pain, and cognitive dysfunction

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Additionally, helpful findings on history include pain and easy bruising in affected areas and a family history of similar traits in other female members

The MAC trial, a randomised crossover study from Loma Linda University, enrolled 35 overweight and obese adults with abdominal obesity and at least one additional cardiometabolic risk factor