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Safety is based on the peptide, dose, and timing

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Involvement of the mesolimbic dopamine system in mediating the aversive effects of opioid antagonists in the rat

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doi: 10.1186/s12970-018-0218-y 554 KeliSOHertogMGFeskensEJKromhoutD

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J Clin Pharm Ther 36:327335 Whitcomb DC, Block GD (1994) Association of acetaminophen hepatotoxicity with fasting and ethanol use

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This is important for autoimmune diseases, because one of the root causes of autoimmune diseases is toxicity from heavy metals, mold, chemicals and potentially medications

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