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Action mechanisms of metformin combined with exenatide and metformin only in the treatment of PCOS in obese patients

This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

A pooled analysis of 16 phase IIIa RCTs from the SUSTAIN and PIONEER trials (11,159 patients) found that 39.1% to 41.9% of subcutaneous and oral semaglutide, respectively, reported GI AEs compared to 22.0% to 24.8% with its comparators [23]

Tapering should only be done under medical supervision

SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1 signaling pathway