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Free radicals are a natural, but undesirable, biproduct of cellular energy metabolism

5,6 For example, free radicals play a role in detoxification of xenobiotics by oxidizing enzymes, in killing of microorganisms by macrophages and cytotoxic lymphocytes, and in the generation of prostaglandins and leukotrienes, which activate oxygenases (e.g., cyclooxygenases and lipoxygenase) and thus act as modulators of the inflammatory response

[DOI] [PubMed] [Google Scholar] 5.Park J.M., Lee H.J., Sikiric P., Hahm K.B

Why site rotation matters Injecting in the same spot repeatedly causes lipohypertrophy, which is a buildup of fatty tissue under the skin at the injection site

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