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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

Wang YM, Yang Q, Xu H et al (2020b) Physiological and transcriptomic analysis provide novel insight into cobalt stress responses in willow

This peptide-metal complex is found endogenously in human plasma, saliva, and urine, and it plays a central role in the bodys tissue repair signaling

doi: 10.3389/fendo.2018.00387 7 NauckMAQuastDRWefersJPfeifferAFH