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In accordance with earlier studies using DACRAs [16, 17], KBP-089 (2.5 g/kg) markedly reduced gastric emptying after both short- and long-term treatment

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1 and summarized in Table 1, the TPMO framework follows a structured progression: the neoadjuvant phase focuses on surgical optimization, the surgery (core) phase aims for a definitive metabolic reset, and the adjuvant phase is designed for long-term maintenance to prevent metabolic adaptation

This change suggests a potent hepatoprotective and anti-apoptotic impact, lowering age-related vulnerability to hepatocyte damage

doi: 10.1186/s12936-016-1674-y