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Neurology (2003) 61:50615.10.1212/01.WNL.0000078939.64774.1B 96 RamaekersVTSequeiraJMArtuchRBlauNTemudoTOrmazabalAet alFolate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome

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They suggested that the hydroxyl group of Thr391 (in EcGGT) acts as a nucleophile for proteolytic cleavage of scissile peptide bond with the preceding residue Gln390