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As a result, current clinical guidelines for T2DM, kidney disease, and cardiovascular care strongly recommend the use of GLP-1RAs and SGLT2is in patients with T2DM who have, or are at high risk for, atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), or chronic kidney disease (CKD)

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For cell cycle proteins to play a role in regulating the cell cycle, they must bind to CDK in order to have kinase activity that phosphorylates cell cycle-associated proteins, thus playing a key role in cell cycle regulation

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