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Patients receiving vedolizumab were more likely to achieve clinical remission and endoscopic remission at 12 months

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This gradual escalation allows the gastrointestinal system to adapt and typically produces better tolerability than jumping directly to higher doses

less allows better absorption

doi: 10.1530/EJE-10-0419 16 ButlerPWSmithSMLindermanJDBrychtaRJAlberobelloATDubazOMet al