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These characteristics make SAMP8 mice particularly suitable for investigating sporadic AD and its progression (Table 6)

In line with this theory, familial hemiplegic migraine type 2 (FHM2) mice, who are genetically predisposed to migraine, have been shown to have lower GABA and higher glutamate levels in the thalamus compared to wild-type mice 31

Glutathione peroxidase Glutathione peroxidase is a tetrameric protein (85 KDa), which has four atoms of selenium bound as selenocysteine moieties that confer catalytic activity [91]

Furthermore, L-citrulline is not extracted from the systemic circulation for hepatic clearance [3]

Key Takeaways Vitamin B12 is vital for neurological function and DNA synthesis