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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Ong K.L., Stafford L.K., McLaughlin S.A

As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34

In vitro models of AD, PD and MS have demonstrated that SFN is efficient in counteracting cell death, neuroinflammation, oxidative stress and protein-aggregation induced by various toxins such as A plaques, LPS, 6-OHDA or hydrogen peroxide, through upregulation of the NRF2/ARE-axis (Table 2)

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