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Terminal differentiation, occurring in the granular compartment, is characterized by flattening of cells, enucleation, and finally cell death leading to sloughing of the cells off the skin surface

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SURMOUNT-1 results (72 weeks, adults with obesity): 5 mg dose: approximately 15% body weight loss 10 mg dose: 19.5% body weight loss 15 mg dose: 22.5% body weight loss Placebo: 3.1% body weight loss At the 15 mg maximum dose, the average participant lost about 52 pounds over 72 weeks

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