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While glucocorticosteroids and antimalarial drugs have historically formed the backbone of treatment, their long-term use is associated with serious side effects and complications (Table 2)

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In much of the clinical research, TB-500 is described as systemic supportmeaning its often framed as a peptide that can influence broader recovery signaling rather than only localized tissue effects

doi:10.1271/bbb1961.46.2057.