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For instance, changes in the composition of this phospholipid layer have been observed by researchers, along with their detrimental effects on the bones and joints of individuals with OA.394 Surprisingly, GLP-1RAs can influence the phospholipid structure and cytokines surrounding joints, leading to beneficial transformations that safeguard joints and even facilitate partial repair of any existing damage.395 (Fig

The mechanisms described below reflect current scientific understanding, including data from the 2023 phase 2 trial published in the New England Journal of Medicine (NEJM), as well as preclinical and mechanistic research