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176 Collectively, these advances underscore a fundamental conceptual shift: proteostasis must now be viewed not as a collection of isolated degradation mechanisms but as a coherent, adaptive, and deeply integrated cellular defense network whose resilience determines disease trajectory

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10.1016/j.pharmthera.2011.10.006 170 ZhuD.LiangR.LiuY.LiZ.ChengL.RenJ.et al (2022)