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The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Jarocka-Karpowicz I., Biernacki M., Wroski A., Ggotek A., Skrzydlewska E

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