In Section Effects of polymorphisms in glucoronosyl transferases we showed that polymorphisms in the glucoronosyl transferase enzymes can have a large effect on the amount of liver damage caused by moderate overdoses of APAP
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Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype
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Preclinical studies have demonstrated that TMAO can induce apoptosis in various target cells, such as human aortic vascular smooth muscle cells, 158 pancreatic acinous cells, renal tubular epithelial cells, 159 human aortic endothelial cells, 160,161 and neurons, 119 contributing to the development and progression of cardiovascular, renal, neurological, and pancreatic diseases
