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A 2025 systematic review in Orthopaedic Sports Medicine analyzed 36 studies on BPC-157 and found that the peptide improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bone injury models

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Constipation and diarrhea each affected roughly 10-16% of participants

Nerve damage takes a long time to heal that is why there is no limit on the administration of B12 injections in those suffering neurological symptoms

As a research peptide, BPC-157 has not undergone the same large-scale clinical safety trials as approved pharmaceuticals